Not a great city, but a good jumping off place for lots of activities. Far enough west that it makes Rincon, Guanica, and other costal cities very accessible. There are great hikes and trips around Mayaguez - there is amazing jungle and rainforest there! Music and activities in the city center around Christmas time, but otherwise not much going on.
You can do lots of shopping here, or enjoy a leisurely stroll. Home of the renowned Colegio Catolico.[Catholic University] Also has the VA Medical Center among its Hospitals.